SML1482
Ogerin
≥98% (HPLC)
Sinónimos:
2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol, [2-[4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C17H17N5O
Número CAS:
Peso molecular:
307.35
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
SMILES string
OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1
InChI
1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
InChI key
MDGIEDNDSFMSLP-UHFFFAOYSA-N
Application
Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Other Notes
Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Discovery of new GPCR ligands to illuminate new biology
Roth B L, et al.
Nature chemical biology, 13(11), 1143-1143 (2017)
Xi-Ping Huang et al.
Nature, 527(7579), 477-483 (2015-11-10)
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selective ligands, hindering the determination of their biological functions and clinical relevance. Among these is GPR68, a proton