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T0557

Taurodesoxicolato de sodio hydrate

BioXtra, ≥97% (TLC)

Sinónimos:

Ácido 2-([3α,12α-dihidroxi-24-oxo-5β-colan-24-il]amino)etanosulfónico, Ácido taurodesoxicólico sodium salt hydrate

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Fórmula lineal:
C26H44NO6SNa · xH2O
Número CAS:
207737-97-1
Peso molecular:
521.69 (anhydrous basis)
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24899897
MDL number:
MFCD00149238
Beilstein/REAXYS Number:
3901204
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description

anionic

Quality Level

200

product line

BioXtra

assay

≥97% (TLC)

mol wt

micellar avg mol wt 3100

aggregation number

6

impurities

≤0.002% Phosphorus (P), ≤0.1% Insoluble matter

CMC

1-4 mM (20-25°C)

solubility

H2O: 0.5 M, clear, colorless to faintly yellow

anion traces

chloride (Cl-): ≤0.5%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.01%, Mg: ≤0.005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

General description

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Application

Detergente aniónico relacionado con las sales biliares utilizado para el aislamiento de las proteínas de membrana, entre ellas las proteínas de la membrana mitocondrial interna.
Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000535598
0000535598
0000509022
0000509022
0000496173

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Emanuel Berger et al.
Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)
Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to
Stefanie Mühlfeld et al.
Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was
Salma Alavi et al.
Cell, 181(7), 1533-1546 (2020-07-08)
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models
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