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T7750

2-Thiouracil

Name: 2-Thiouracil
Brand: SIGMA

≥99%, synthetic, powder

Sinónimos:

(2-thioxo -2, 3-dihydropyrimidin-4(1H)-one), 2TU, 4-Hydroxy-2-mercaptopyrimidine

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Fórmula empírica (notación de Hill):

C₄H₄N₂OS

Número CAS:

141-90-2

Peso molecular:

128.15

NACRES:

NA.51

PubChem Substance ID:

24900470

UNSPSC Code:

41106305

EC Number:

205-508-8

MDL number:

MFCD00006039

Beilstein/REAXYS Number:

112227

Assay:

≥99%

Biological source:

synthetic

Form:

powder

Solubility:

1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow

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Propiedades

Nombre del producto

2-Thiouracil, ≥99%

biological source

synthetic

Quality Segment

200

assay

≥99%

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow

SMILES string

O=C1NC(=S)NC=C1

InChI

1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI key

ZEMGGZBWXRYJHK-UHFFFAOYSA-N

Descripción

General description

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase.This antithyroid drug has less solubility in H₂O & organic solvents.

Application

2-Thiouracil may be used:

in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)
to study its electro-oxidation and determination at titanium dioxide (TiO2) nanoparticles-modified gold electrode
to study the effect of methylation on the deactivation mechanism or the triplet-state dynamics of 2-thiouracil using time-resolved photoelectron spectroscopy

Biochem/physiol Actions

2-Thiouracil acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), chromium (Cr), zinc (Zn), and silver (Ag).2-thiouracil can be incorporated into the tissue culture medium to inhibit virus replication or movement from infected to healthy tissues during chemotherapy.

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pictograms

GHS08

signalword

Warning

hcodes

H351

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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