S6942
Staurosporine solution from Streptomyces sp.
Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Synonym(s):
Antibiotic AM-2282
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About This Item
Assay:
>98% (HPLC)
Quality level:
Product Name
Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Quality Level
assay
>98% (HPLC)
concentration
1 mM in DMSO (100 μg/214 μL)
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
General description
Chemical structure: indol derivative
Application
Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4
Biochem/physiol Actions
Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Suainibhe Kelly et al.
Nanoscale, 13(41), 17615-17628 (2021-10-19)
The use of nanomaterials as therapeutic delivery vehicles requires their careful pre-clinical evaluation. Of particular importance in this regard is measurement of cellular toxicity, ideally assessing multiple parameters in parallel from various relevant subcellular organelles. In recent years it has
Jan Roger Olsen et al.
PloS one, 8(5), e62547-e62547 (2013-05-10)
The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT. We therefore investigated the role
Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two