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568500

SQ 22536

Name: SQ 22536
Brand: MM

≥98% (HPLC), adenylate cyclase inhibitor, solid

Synonyme(s) :

SQ 22536, 9-(Tetrahydro-2ʹ-furyl)adenine

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A propos de cet article

Formule empirique (notation de Hill) :

C₉H₁₁N₅O

Numéro CAS:

17318-31-9

Poids moléculaire :

205.22

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00210216

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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Propriétés

Nom du produit

SQ 22536, Cell-permeable adenylate cyclase inhibitor.

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 25 mg/mL, water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]2(c3ncnc(c3nc2)N)C1OCCC1

InChI

1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)

InChI key

UKHMZCMKHPHFOT-UHFFFAOYSA-N

Description

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC₅₀ = 200 µM). Reduces PGE₂-induced inhibition of O₂^·– production.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
adenylate cyclase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 200 µM against adenylate cyclase

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c