A2327
Adrenomedullin 52 human
≥90% (HPLC), powder
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About This Item
Empirical Formula (Hill Notation):
C264H406N80O77S3
CAS Number:
Molecular Weight:
6028.73
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
General description
Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.
Application
Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions
Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis.
Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3.
Robinson, SD et al.
Journal of Pharmacology and Experimental Therapeutics, 331(2), 513-521 (2009)
Adrenomedullin in the growth modulation and differentiation of acute myeloid leukemia cells.
Di Liddo R, et al.
International Journal of Oncology, 48(4), 1659-1669 (2016)
Yosuke Suzuki et al.
Journal of peptide science : an official publication of the European Peptide Society, 19(1), 59-63 (2012-12-12)
Adrenomedullin (ADM) is a 52-amino acid peptide with a variety of physiologic functions such as immunomodulating activity, direct bactericidal activity, maintenance of renal homeostasis, and vasodilatory activity. Midregional proADM (MR-proADM) is derived from a larger 185-amino acid precursor peptide, prepro-adrenomedulin