C1055
Cromakalim
Synonym(s):
(±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H18N2O3
CAS Number:
Molecular Weight:
286.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
storage temp.
2-8°C
SMILES string
CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
InChI
1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI key
TVZCRIROJQEVOT-CABCVRRESA-N
Gene Information
rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)
Application
Cromakalim has been used:
- as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
- as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
- as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.
Biochem/physiol Actions
Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
C Boselli et al.
European journal of pharmacology, 335(1), 23-30 (1997-11-26)
Contraction of the rat detrusor muscle is mediated by cholinergic and purinergic mechanisms. The present study was carried out to look at the influence of cromakalim, compared with atropine, suramin and nifedipine on the contractile response evoked by single shock
M C Sanguinetti et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(21), 8360-8364 (1988-11-01)
The mechanism by which the antihypertensive agent BRL 34915 (cromakalim) affects action potential duration (APD) and effective refractory period (ERP) in isolated cardiac muscle was investigated. BRL 34915 (greater than or equal to 3 microM) shortened ERP of ferret (Mustela
Omonkhelin J Owolabi et al.
Journal of diabetes, 5(1), 88-94 (2013-02-05)
Levcromakalim is a vasorelaxant used in the management of hypertension in diabetes mellitus. Thus, the effects of levcromakalim were investigated in streptozotocin (STZ)-diabetic rats. Diabetes was induced in Wistar albino rats with a single injection of STZ (60 mg/kg, i.p.)