C6240
CITCO
≥98% (HPLC), androstane receptor agonist, solid
Synonym(s):
6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
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About This Item
Empirical Formula (Hill Notation):
C19H12N3OCl3S
CAS Number:
Molecular Weight:
436.74
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
CITCO, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: soluble 28 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChI key
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
General description
CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.
Application
CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.
Biochem/physiol Actions
CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Jodi M Maglich et al.
The Journal of biological chemistry, 278(19), 17277-17283 (2003-03-04)
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical stress. Identification of CAR target genes in humans has been limited by the lack of a selective CAR agonist. We report