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EHU010481

MISSION® esiRNA

targeting human CST5

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324
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description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGCTTTGCTCTCTGGGAGATCCAGCTCCTTGCTCTGTGTCCCAGTAGAACATGATGTGGCCCATGCACACCCCACTGCTGCTGCTGACTGCCTTGATGGTGGCCGTGGCCGGGAGTGCCTCGGCCCAATCTAGGACCTTGGCAGGTGGCATCCATGCCACAGACCTCAATGACAAGAGTGTGCAGTGTGCCCTGGACTTTGCCATCAGCGAGTACAACAAGGTCATTAATAAGGATGAGTACTACAGCCGCCCTCTGCAGGTGATGGCTGCCTACCAGCAGATCGTGGGTGGGGTGAACTACTACTTCAATGTGAAGTTCGGTCGAACCACATGCACCAAGTCCCAGCCCAACTTGGACAACTGTCCCTTCAATGACCAGCCAAAACTGAAAGAGGAAGAGTTCTGCTCTTTCCAGATCAATGAAGTTCCCTGGGAGGATAAAATTTCCATTCTGAACTACAAGTGCCGGAAAGTCTAGGGGTCTGTGCAAGGCCTGTCACACTGACCACCTCCTACTCCCAC

Ensembl | human accession no.

ENSG00000170367

NCBI accession no.

NM_001900

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CST5(1473)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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MISSION esiRNA

Instructions

Gemma Ferrer-Mayorga et al.
The Journal of biological chemistry, 290(44), 26533-26548 (2015-09-15)
Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit proliferation, migration, and invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease inhibition. Here, we demonstrate
Sabine Hünten et al.
Oncotarget, 6(18), 15842-15856 (2015-07-15)
Cystatin D (CST5) encodes an inhibitor of cysteine proteases of the cathepsin family and is directly induced by the vitamin D receptor (VDR). Interestingly, vitamin D3 exerts tumor suppressive effects in a variety of tumor types. In colorectal cancer (CRC)