I2660
IRAK2, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
MG C150550
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
5-7 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
5-7 nmol/min·mg
mol wt
~103 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IRAK2(3656)
Biochem/physiol Actions
IRAK2 (interleukin-1 receptor-associated kinase 2) belongs to the IRAK family and is ubiquitously expressed. The protein contains an amino terminal death domain and a central kinase domain. IRAK2 is required for TLR (Toll-like receptor) signaling. Upon activation of TLR4 and TLR8, IRAK2 is crucial for the induction of TNF (tumor necrosis factor). It also regulates endoplasmic reticulum stress signaling.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Related Content
Samir Benosman et al.
PloS one, 8(5), e64256-e64256 (2013-06-01)
Endoplasmic reticulum (ER) stress occurs when unfolded proteins accumulate in the lumen of the organelle, triggering signal transduction events that contribute either to cellular adaptation and recovery or alternatively to cellular dysfunction and death. ER stress has been implicated in
H Wesche et al.
The Journal of biological chemistry, 274(27), 19403-19410 (1999-06-26)
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family. We now report the identification and characterization of a
Weina Zhang et al.
The Journal of biological chemistry, 289(18), 12507-12519 (2014-03-26)
The IL-1 receptor-associated kinases (IRAKs) are key regulators of Toll-like receptor (TLR)/IL-1 signaling, which are critical regulators of mammalian inflammation and innate immune response. Single nucleotide polymorphisms (SNPs) within the IRAK genes have been discovered recently. However, the functions of