S4443
SCH-28080
≥98% (HPLC), gastric H+ and K+-ATPase inhibitor, solid
Synonym(s):
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
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About This Item
Empirical Formula (Hill Notation):
C17H15N3O
CAS Number:
Molecular Weight:
277.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Product Name
SCH-28080, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to light tan
solubility
DMSO: soluble >10 mg/mL, H2O: insoluble
compatibility
for use with ABI 7700
storage temp.
−20°C
SMILES string
Cc1nc2c(OCc3ccccc3)cccn2c1CC#N
InChI
1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
InChI key
PYKJFEPAUKAXNN-UHFFFAOYSA-N
Application
SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development.
Biochem/physiol Actions
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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