SCP0093
Caspase Inhibitor
≥95% (HPLC)
Synonym(s):
Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor
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About This Item
Empirical Formula (Hill Notation):
C21H34N4O10
Molecular Weight:
502.52
NACRES:
NA.32
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Gene Information
human ... CASP8(841), CASP9(842)
Application
Caspase inhibitor Ac-LETD-CHO has been used to inhibit caspase-8.
Biochem/physiol Actions
The peptide Ac-Leu-Glu-Thr-Asp-al, or Ac-LETD-CHO, is a known caspase inhibitor. Ac-LETD-CHO has been reported to exert inhibitory effects on caspase 8 and on caspase 9.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jie Shi et al.
Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been
Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways
Lara M
Scientific Reports (2017)
Apoptotic Regulation of Caspase Activity
Martinova, E.A., et al.
Russian J. Bioorg. Chem., 29, 471-495 (2003)