204896 Complement C8, Human

204896
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      Přehled

      Replacement Information

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      204896-250UG
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          Plastová ampulka 250 μg
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          Description
          OverviewNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
          Catalogue Number204896
          Brand Family Calbiochem®
          References
          ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
          Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
          Product Information
          CAS number80295-58-5
          FormLiquid
          FormulationIn PBS, pH 7.2.
          Quality LevelMQ200
          Applications
          Biological Information
          Purity≥85% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥150,000 C₈H₅0 units/mg
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Complement C8, Human MSDS

          Title

          Safety Data Sheet (SDS) 

          Complement C8, Human Certificates of Analysis

          TitleLot Number
          204896

          References

          Přehled odkazů
          Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
          Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-August-2009 RFH
          DescriptionNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64,000 (α), 64,000 (β), and 22,000 (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8, resulting in formation of C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
          FormLiquid
          FormulationIn PBS, pH 7.2.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number80295-58-5
          Purity≥85% by SDS-PAGE
          ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
          Specific activity≥150,000 C₈H₅0 units/mg
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
          Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.