239764 Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₁₅H₂₃NO₄ 66-81-9

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      239764-100MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Skleněná láhev 100 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          239764-1GM
          Zjišťuji dostupnost...
          Omezená dostupnostOmezená dostupnost
          Na skladě 
          Přerušeno
          Dostupné omezené množství
          Dostupnost bude potvrzena
            Remaining : Will advise
              Remaining : Will advise
              Bude poskytnuto
              Kontaktujte Zákaznický servis
              Contact Customer Service

              Hliníkový sud 1 gm
              Zjišťuji cenu...
              Cenu nelze zjistit
              Minimum Quantity needs to be mulitiple of
              S dokončenou objednávkou Další informace
              Ušetřili jste ()
               
              Vyžádat nacenění
              Description
              OverviewAntifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
              Catalogue Number239764
              Brand Family Calbiochem®
              References
              ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Product Information
              CAS number66-81-9
              FormWhite solid
              Hill FormulaC₁₅H₂₃NO₄
              Chemical formulaC₁₅H₂₃NO₄
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationCycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.
              Biological Information
              Primary TargethFKBP12
              Primary Target K<sub>i</sub>3.4 µM
              Purity≥98% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSMA4375000
              Safety Information
              R PhraseR: 28-40-51/53-61

              Very toxic if swallowed.
              Limited evidence of a carcinogenic effect.
              Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
              May cause harm to the unborn child.
              S PhraseS: 45-53-61

              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Avoid exposure - obtain special instructions before use.
              Avoid release to the environment. Refer to special instructions/safety data sheet.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem MSDS

              Title

              Safety Data Sheet (SDS) 

              Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              239764

              References

              Přehled odkazů
              Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.

              Brochure

              Title
              Tools and Tips for Analyzing Apoptosis

              Citations

              Název
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision29-April-2008 RFH
              DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
              FormWhite solid
              CAS number66-81-9
              RTECSMA4375000
              Chemical formulaC₁₅H₂₃NO₄
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityChloroform, Ethanol, and Methanol
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Merck USA index14, 2728
              ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Citation
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.