373386 Hh Signaling Pathway Modulators

373386
  
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      Replacement Information
      Description
      Overview

      This product has been discontinued.



      A panel containing 14 potent, selective and cell-permeable antagonists, inhibitors and agonists that are useful for the study of the Hh (Hedgehog) signaling pathway: 5 mg of βARK1 Inhibitor (Cat. No. 182200), 100 µg of Cyclopamine-KAAD (Cat. No. 239804), 25 mg of Fluvastatin, Sodium Salt (Cat. No. 344095), 1 mg of GSK-3 Inhibitor IX; BIO (Cat. No. 361550), 1 mg of H-89, Dihydrochloride (Cat. No. 371963), 10 mg of Hh Signaling Antagonist XIV; SANT-2 (Cat. No. 373273), 10 mg of Hh Signaling Antagonist XII; HPI-1 (Cat. No. 373275), 10 mg of Hh Signaling Antagonist XIII; HPI-3 (Cat. No. 373276), 5 mg of Hh/Gli Antagonist; GANT61 (Cat. No. 373401), 5 mg of Hh Signaling Antagonist VII; JK184 (Cat. No. 373385), 5 mg of IC261 (Cat. No. 400090), 5 mg of MG-132 (Cat. No. 474790), 5 mg of Purmorphamine (Cat. No. 540220) and 1 mg of Smoothened Agonist; SAG (Cat. No. 566660). Also provided with 15 ml of anhydrous DMSO (Cat. No. KP31817). Supplied with a data sheet.

      Catalogue Number373386
      Brand Family Calbiochem®
      Application Data
      References
      ReferencesPeukert, S. and Miller-Moslin, K., 2010. Chem. Med. Chem. 6, 500.
      Tremblay, M.R., et al. 2010. Curr. Opin. Chem. Biol. 14, 428.
      Scales, S.J. and de Sauvage, F. J., 2009. Trends. Pharmacol. Sci. 30, 303.
      Jiang, J. and Hui, C.C., 2008. Dev. Cell 15, 801.
      Lum, L. and Beachy, P.A, 2004. Science 304, 1755
      Ingham, P.W. and McMohan, A.P., 2001. Genes Dev. 15, 3059.
      Product Information
      FormSolid
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22-36/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes and skin.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Hh Signaling Pathway Modulators MSDS

      Title

      Safety Data Sheet (SDS) 

      Hh Signaling Pathway Modulators Certificates of Analysis

      TitleLot Number
      373386

      References

      Přehled odkazů
      Peukert, S. and Miller-Moslin, K., 2010. Chem. Med. Chem. 6, 500.
      Tremblay, M.R., et al. 2010. Curr. Opin. Chem. Biol. 14, 428.
      Scales, S.J. and de Sauvage, F. J., 2009. Trends. Pharmacol. Sci. 30, 303.
      Jiang, J. and Hui, C.C., 2008. Dev. Cell 15, 801.
      Lum, L. and Beachy, P.A, 2004. Science 304, 1755
      Ingham, P.W. and McMohan, A.P., 2001. Genes Dev. 15, 3059.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-March-2011 RFH
      Application Data
      DescriptionA panel containing 14 potent, selective and cell-permeable antagonists, inhibitors and agonists that are useful for the study of the Hh (Hedgehog) signaling pathway. The panel contains the following inhibitors and 15 ml anhydrous DMSO for reconstitution:
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      SolubilityDMSO (supplied). Please refer to information provided on the CD for reconstitution of individual inhibitors.
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Harmful
      ReferencesPeukert, S. and Miller-Moslin, K., 2010. Chem. Med. Chem. 6, 500.
      Tremblay, M.R., et al. 2010. Curr. Opin. Chem. Biol. 14, 428.
      Scales, S.J. and de Sauvage, F. J., 2009. Trends. Pharmacol. Sci. 30, 303.
      Jiang, J. and Hui, C.C., 2008. Dev. Cell 15, 801.
      Lum, L. and Beachy, P.A, 2004. Science 304, 1755
      Ingham, P.W. and McMohan, A.P., 2001. Genes Dev. 15, 3059.