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194950 InSolution™ 3ʹ-Azido-3ʹ-Deoxythymidine, Triphosphate, Tetralithium Salt

194950
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₀H₁₂N₅O₁₃P₃ · 4Li
Description
Overview

This product has been discontinued.





A reverse transcriptase inhibitor that acts by docking to the active site of HIV reverse transcriptase. It's inhibitory effect is greater during the initiation phase of reverse transcription. Also reported to inhibit telomerase activity in vitro (IC50 = 30 µM). Acts synergistically with Cisplatin (Cat. No. 232120) to inhibit cell proliferation in some cell lines.
Note: 1 µmol = 531 µg.
Catalogue Number194950
Brand Family Calbiochem®
SynonymsAZTTP
References
ReferencesMickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.
Product Information
FormLiquid
FormulationA 100 mM solution in H₂O.
Hill FormulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
Chemical formulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targettelomerase activity
Primary Target IC<sub>50</sub>30 µM
Secondary targetreverse transcriptase
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ 3ʹ-Azido-3ʹ-Deoxythymidine, Triphosphate, Tetralithium Salt Certificates of Analysis

TitleLot Number
194950

References

Přehled odkazů
Mickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-September-2007 RFH
SynonymsAZTTP
DescriptionA reverse transcriptase inhibitor that acts by docking to the active site of HIV-reverse transcriptase. Inhibitory effect is greater during the initiation phase of reverse transcription. Also reported to inhibit telomerase activity in vitro (IC50 = 30 µM). Acts synergistically with cisplatin to inhibit cell proliferation in some cell lines.
FormLiquid
FormulationA 100 mM solution in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Toxic
ReferencesMickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.