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492040 Nrf2 Activator - Calbiochem

The Nrf2 Activator modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Nrf2 Activator - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II

492040
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₇H₁₃F₃O₂
Description
OverviewA cell-permeable chalcone that effectively activates NQO1 (NADPH-/quinone oxidoreductase 1) ARE- (antioxidant response element) mediated reporter transcription in human bronchial epithelial Beas-2B cells (7.0-fold of control; 20 µM compound) and induces Nrf2- (Nuclear factor erythroid 2 p45-related factor 2) regulated antioxidants and cytoprotective genes transcription, including GCLM (glutamate-cysteine ligase modifier subunit), NQO1, and HO1 (heme oxygenase-1), both in cultures ([compound] = 10 to 20 µM) in vitro and in mice (50 mg/kg p.o.) in vivo.
Catalogue Number492040
Brand Family Calbiochem®
Synonyms(E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II
References
ReferencesKumar, V., et al. 2011. J. Med. Chem. 54, 4147.
Product Information
FormYellow syrup
Hill FormulaC₁₇H₁₃F₃O₂
Chemical formulaC₁₇H₁₃F₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
492040 0

Documentation

Nrf2 Activator - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Nrf2 Activator - Calbiochem Certificates of Analysis

TitleLot Number
492040

References

Přehled odkazů
Kumar, V., et al. 2011. J. Med. Chem. 54, 4147.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-May-2012 JSW
Synonyms(E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II
DescriptionA cell-permeable chalcone that is shown to effectively activate NQO1 (NADPH/quinine oxidoreductase 1) ARE- (antioxidant response element) mediated reporter transcription in human bronchial epithelial Beas-2B cells (6.3- and 7.0-fold of control, respectively, with 10 and 20 µM compound) and induce Nrf2- (Nuclear factor erythroid 2 p45-related factor 2) regulated antioxidants and cytoprotective genes transcription, including GCLM (glutamate-cysteine ligase modifier subunit), NQO1, and HO1 (heme oxygenase-1), both in Beas-2B cultures (4-, 6.7-, and 178-fold, respectively, of basal NQO1/24 h, GCLM/6 h, and HO1/6 h mRNA level; [compound ] = 10 µM) in vitro and in mice (6- and 10-fold, respectively, of control GCLM and NQO1 mRNA level in small intestine 24 h after single p.o. dosage of 50 mg/kg) in vivo. The drug's cellular target(s) and mechanism of action is unknown, but likely involves covalent thio modification of the target(s) by the compound's electrophilic enone moiety.
FormYellow syrup
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₃F₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesKumar, V., et al. 2011. J. Med. Chem. 54, 4147.