S1445
Anti-Somatostatin Receptor Type 1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-SSTR1
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8 μg/mL using human pancreas, Islets of Langerhans
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SSTR1(6751)
mouse ... Sstr1(20605)
rat ... Sstr1(25033)
General description
Somatostatin Receptor Type 1 (SSTR1) is present in blood vessels, neuroendocrine cells, and the retina. SSTR1 gene is mapped to human chromosome 14q21.1.
Immunogen
synthetic peptide corresponding to the C-terminal of human somatostatin receptor type 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Biochem/physiol Actions
Somatostatin Receptor Type 1 (SSTR1) protein extracellular loop regions are crucial for ligand binding. SSTR1 gene down-regulated in reported in preeclampsia but it is overexpressed in breast cancer. It is reported to block the mitogen-activated protein kinase (MAPK) pathway. However, in pancreatic cell lines, elevated expression of SSTR1 gene favors cell cycle arrest. SSTR1 also plays a tumor suppressor role in gastric cancer invasion.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Instructions
Santhosh Kumar Nagarajan et al.
ACS omega, 5(33), 21145-21161 (2020-09-03)
Somatostatin receptor 1 (SSTR1), a subtype of somatostatin receptors, is involved in various signaling mechanisms in different parts of the human body. Like most of the G-protein-coupled receptors (GPCRs), the available information on the structural features of SSTR1 responsible for
J Zhao et al.
British journal of cancer, 108(12), 2557-2564 (2013-06-01)
Somatostatin receptor 1 (SSTR1) was preferentially methylated in Epstein-Barr virus (EBV)-positive gastric cancer using promoter methylation array. We aimed to analyse the epigenetic alteration and biological function of SSTR1 in EBV-associated gastric cancer (EBVaGC). Promoter methylation was examined by combined
Yi Zou et al.
Oncology letters, 17(2), 1723-1731 (2019-01-25)
Somatostatin receptors (SSTRs) are G-protein-coupled plasma membrane receptors that have been determined to be expressed in normal and cancer tissues. Activation of SSTRs frequently results in inhibition of cell proliferation and therefore somatostatin analogues (SSAs) have been used in cancer