SML2538
KL-2
≥98% (HPLC)
Synonym(s):
N-(5-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxo-2-butenamide
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About This Item
Empirical Formula (Hill Notation):
C17H13ClFNO3
CAS Number:
Molecular Weight:
333.74
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=CC=C(Cl)C=C1NC(/C(O)=C/C(C2=CC=C(F)C=C2)=O)=O
Biochem/physiol Actions
Disruptor of SEC (super elongation complex)
KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kaiwei Liang et al.
Cell, 175(3), 766-779 (2018-10-20)
The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases