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Merck

202495

Poly(ethylene glycol) methyl ether

average MN 750, methoxy, hydroxyl

Synonym(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
9004-74-4
UNSPSC Code:
12162002
PubChem Substance ID:
24852093
NACRES:
NA.23
MDL number:
MFCD00084416

Key Documents

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Product Name

Poly(ethylene glycol) methyl ether, average Mn 750

SMILES string

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

form

paste, solid

mol wt

average Mn 750

refractive index

n20/D 1.459

viscosity

10.5 cSt(210 °F)(lit.)

transition temp

Tm 30 °C

density

1.094 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methoxy

Quality Level

200

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Application

Poly(ethylene glycol) methyl ether can be used:
  • As a chain transfer agent to synthesize amphiphilic block copolymers by metal-free ring-opening oligomerization.
  • As a precursor to prepare retinoic acid-polyethylene glycol nanoassembly as an efficient drug delivery system.
  • To prepare diblock copolymer with polylactic acid, which can be applied in the field of tissue engineering and drug delivery.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

359.6 °F - closed cup

flash_point_c

182 °C - closed cup

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8777
MKCW3308
0000214565
0000214565
MKCV2901

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Yi Wei et al.
Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
Junhwa Shin et al.
Molecular pharmaceutics, 9(11), 3266-3276 (2012-10-04)
A family of 3-methoxypoly(ethylene glycol)-vinyl ether-1,2-dioleylglycerol (mPEG-VE-DOG) lipopolymer conjugates, designed on the basis of DFT calculations to possess a wide range of proton affinities, was synthesized and tested for their hydrolysis kinetics in neutral and acidic buffers. Extruded ∼100 nm
Yunki Lee et al.
Colloids and surfaces. B, Biointerfaces, 102, 585-589 (2012-10-30)
The control of biological interactions that occur at material-cell/blood interfaces is of great importance to help maximize in vitro and in vivo performance of biomedical devices. PEGylation has been extensively used as an effective surface modification tool that can alter
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
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