440167
(3-Glycidyloxypropyl)trimethoxysilane
≥98%
Synonym(s):
3-(2,3-Epoxypropoxy)propyltrimethoxysilane, GLYMO, Glycidyl 3-(trimethoxysilyl)propyl ether
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About This Item
Empirical Formula (Hill Notation):
C9H20O5Si
CAS Number:
Molecular Weight:
236.34
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
219-784-2
Beilstein/REAXYS Number:
4308125
MDL number:
Quality Level
assay
≥98%
form
liquid
refractive index
n20/D 1.429 (lit.)
bp
120 °C/2 mmHg (lit.)
density
1.07 g/mL at 25 °C (lit.)
SMILES string
CO[Si](CCCOCC1CO1)(OC)OC
InChI
1S/C9H20O5Si/c1-10-15(11-2,12-3)6-4-5-13-7-9-8-14-9/h9H,4-8H2,1-3H3
InChI key
BPSIOYPQMFLKFR-UHFFFAOYSA-N
General description
(3-Glycidyloxypropyl)trimethoxysilane (GPTMS) is a high-purity, bifunctional organosilane designed for the seamless integration of biological molecules and organic polymers with inorganic substrates. This ≥98% purity grade is unique for its terminal epoxy (oxirane) ring, which enables "reagent-free" covalent bioconjugation via nucleophilic attack from amines, thiols, or hydroxyls. This reagent is the gold standard for stabilizing conductive polymers and creating 3D-networked hybrid scaffolds, offering a pH-selective reactivity profile that allows for controlled surface modification and superior optical clarity in thin-film applications.
Application
As a versatile molecular bridge, GPTMS is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.
• Reagent-Free Bioconjugation: Enables direct immobilization of proteins, enzymes, and amino-modified DNA onto surfaces without secondary cross-linkers like EDC/NHS. • Conductive Polymer Stabilization: Enhances the electrical stability and mechanical adhesion of PEDOT:PSS films in bio-electronic sensors and neural interfaces. • Tissue Engineering Scaffolds: Functions as a critical cross-linker in chitosan-silica hybrids, significantly improving mechanical stability and biomineralization for bone regeneration. • Nanocarbon Reinforcement: Surface-modifies carbon nanotubes (MWCNTs) to optimize dispersion and interfacial bonding in high-performance nanocomposites for medical implants. • Enzyme Immobilization: Functionalizes silica and magnetic nanoparticles to create high-surface-area biocatalytic platforms for diagnostic assays and pharmaceutical synthesis.
• Reagent-Free Bioconjugation: Enables direct immobilization of proteins, enzymes, and amino-modified DNA onto surfaces without secondary cross-linkers like EDC/NHS. • Conductive Polymer Stabilization: Enhances the electrical stability and mechanical adhesion of PEDOT:PSS films in bio-electronic sensors and neural interfaces. • Tissue Engineering Scaffolds: Functions as a critical cross-linker in chitosan-silica hybrids, significantly improving mechanical stability and biomineralization for bone regeneration. • Nanocarbon Reinforcement: Surface-modifies carbon nanotubes (MWCNTs) to optimize dispersion and interfacial bonding in high-performance nanocomposites for medical implants. • Enzyme Immobilization: Functionalizes silica and magnetic nanoparticles to create high-surface-area biocatalytic platforms for diagnostic assays and pharmaceutical synthesis.
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signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Eye Dam. 1
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Functionalization of carbon nanotubes with (3-glycidyloxypropyl)-trimethoxysilane: Effect of wrapping on epoxy matrix nanocomposites.
Hoepfner, et al.
Journal of Applied Polymer Science, 133(47), 814-820 (2016)
Harun, M.K.; et al.
Progress in Organic Coatings, 4, 317-317 (2005)
Journal of Organometallic Chemistry, 625, 208-208 (2001)