Baicalein

Name: Baicalein
Brand: ALDRICH

98%

Synonym(s):

5,6,7-Trihydroxyflavone

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All Photos(3)

About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₅

CAS Number:

491-67-8

Molecular Weight:

270.24

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24870246

MDL number:

MFCD00017459

Beilstein/REAXYS Number:

272683

Product Name

Baicalein, 98%

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

SMILES string

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI key

FXNFHKRTJBSTCS-UHFFFAOYSA-N

assay

98%

form

solid

mp

256-271 °C (lit.)

functional group

ketone
phenyl

Quality Level

100

Gene Information

mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)

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Application

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

General description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi.

Naheed Riaz et al.

Phytochemistry, 65(8), 1129-1135 (2004-04-28)

Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition

Baicalein preconditioning protects cardiomyocytes from ischemia-reperfusion injury via mitochondrial oxidant signaling.

Wei-Tien Chang et al.

The American journal of Chinese medicine, 41(2), 315-331 (2013-04-04)

Previous studies suggest baicalein, in addition to its antioxidant effects, protects against hypoxia/reoxygenation injury via its pro-oxidant properties. We hypothesize that a brief period of baicalein treatment prior to ischemia/reperfusion (I/R) may trigger preconditioning protection via a mitochondrial pro-oxidant mechanism.

Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein.

Wujun Dong et al.

Acta pharmaceutica Sinica. B, 10(8), 1576-1585 (2020-09-24)

Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within

Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.

Zaijun Zhang et al.

Journal of agricultural and food chemistry, 60(33), 8171-8182 (2012-07-31)

Baicalein, one of the major flavonoids found in Scutellaria baicalensis Georgi, displays neuroprotective effects on experimental models of Parkinson's disease (PD) in vitro and in vivo. Although the antioxidative and/or anti-inflammatory activity of baicalein likely contributes to these neuroprotective effects

The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms.

Ana Roseli S Ribeiro et al.

Chemico-biological interactions, 260, 33-41 (2016-10-27)

Many flavonoids have been shown to present good results for the treatment of gastric ulcers. Baicalein, a bioactive flavonoid derived from the Scutellaria baicalensis Georgi root, possesses several biological effects, such as anti-inflammatory and antioxidant. This study was conducted to

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