900584
5-Ethynyl-2′-deoxyuridine
95%
Synonym(s):
EdU
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About This Item
Empirical Formula (Hill Notation):
C11H12N2O5
CAS Number:
Molecular Weight:
252.22
MDL number:
UNSPSC Code:
12352208
NACRES:
NA.22
Assay:
95%
Form:
powder
Quality Level
assay
95%
form
powder
manufacturer/tradename
(BCN-001)
mp
206 °C
storage temp.
−20°C
SMILES string
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(C#C)=C2)=O)=O)O1
InChI
1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
InChI key
CDEURGJCGCHYFH-DJLDLDEBSA-N
General description
5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analogue that can be incorporated into cellular DNA for cell proliferation studies. The incorporated nucleoside analogue can be detected by a copper-catalyzed click reaction with a fluorescent azide.
Application
5-Ethynyl-2′-deoxyuridine (EdU) is used for:
For a listing of the Baseclick kits see: Baseclick kits
- Labeling newly synthesized DNA during replication
- Cell proliferating assay studies
- Cell cycle analysis
For a listing of the Baseclick kits see: Baseclick kits
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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5-Ethynyl-2?-deoxycytidine as a new agent for DNA labeling: detection of proliferating cells
D Qu, et.al.
Analytical Biochemistry, 417, 112-121 (2011)
Evaluation of 5-ethynyl-2?-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system
C Zeng, et.al.
Brain Research, 1319, 21-32 (2010)
Timothy J Mead et al.
Methods in molecular biology (Clifton, N.J.), 1130, 233-243 (2014-02-01)
Assessing cell proliferation in situ is an important phenotyping component of skeletal tissues from development to adult stages and disease. Various methods exist including immunostaining for proteins and protein modifications associated with specific steps of the cell cycle, but the