I3875
Indoxyl sulfate potassium salt
Synonym(s):
Potassium 3-indoxyl sulfate, Urinary indican
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About This Item
Linear Formula:
C8H6NO4SK
CAS Number:
Molecular Weight:
251.30
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-145-5
Beilstein/REAXYS Number:
3921324
MDL number:
Assay:
> 98 %
InChI
1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1
InChI key
MDAWATNFDJIBBD-UHFFFAOYSA-M
SMILES string
[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12
assay
> 98 %
mp
165 °C (dec.) (lit.)
solubility
water: soluble
storage temp.
−20°C
Quality Level
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General description
Indoxyl sulfate potassium salt is derived from indoxyl sulfate by replacing the hydrogen ion with a potassium cation. Potassium indoxyl sulfate is used as a reagent for the detection and determination of hydrogen peroxide.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hidehisa Shimizu et al.
Life sciences, 92(2), 143-148 (2012-12-04)
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in adhesion of monocytes/macrophages to injured tubulointerstitial tissue. The present study aimed to determine if indoxyl sulfate, a uremic toxin, regulates renal expression of ICAM-1. The effect of indoxyl sulfate on
Tino Vollmer et al.
Scientific reports, 9(1), 14525-14525 (2019-10-12)
Identifying the key toxic players within an in-vivo toxic syndrome is crucial to develop targeted therapies. Here, we established a novel method that characterizes the effect of single substances by means of an ex-vivo incubation set-up. We found that primary
Suree Lekawanvijit et al.
Circulation research, 111(11), 1470-1483 (2012-11-10)
Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists. Despite advances in treatment of both cardiovascular and kidney disease, cardiorenal syndrome remains a major global health problem. Characteristic of the pathophysiology of
Indoxyl sulfate upregulates liver P-glycoprotein expression and activity through aryl hydrocarbon receptor signaling
Machado, et al.
Journal of the American Society of Nephrology, 29, 906-918 (2018)
Carel J Pretorius et al.
Clinica chimica acta; international journal of clinical chemistry, 419, 122-126 (2013-02-23)
The uremic toxins indoxyl sulphate (IS) and p-cresyl sulphate (pCS) are absorbed bacterial metabolites of tryptophan and tyrosine respectively and may be predictive of clinical outcome. Long chromatography times, incomplete data on the reference ranges of the free and total
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