P57204
Pyridazine
98%
Synonym(s):
1,2-Diazabenzene, 1,2-Diazine, o-Diazine
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About This Item
Empirical Formula (Hill Notation):
C4H4N2
CAS Number:
Molecular Weight:
80.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-025-5
Beilstein/REAXYS Number:
103906
MDL number:
Assay:
98%
InChI key
PBMFSQRYOILNGV-UHFFFAOYSA-N
InChI
1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H
SMILES string
c1ccnnc1
assay
98%
refractive index
n20/D 1.524 (lit.)
bp
208 °C (lit.)
mp
−8 °C (lit.)
density
1.103 g/mL at 25 °C (lit.)
Quality Level
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Application
Pyridazine can be used:
- As a building block to synthesize N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine derivatives as GSK-3 inhibitors.
- As a starting material in the synthesis of pharmacologically important pyrrolo[1,2-b]pyridazine derivatives.
- To prepare 1-(6-ethoxy-6-oxohexyl)pyridazin-1-ium bromide and 1-(2-bromoacetyl) pyridazinium bromide ionic liquids as corrosion inhibitors of steel under acidic conditions.
General description
Pyridazine is a mono-basic 1,2-diazine compound, which is commonly prepared by the reaction of 1,4-dicarbonyls with hydrazines. Pyridazine ring is found in many herbicides like credazine, pyridatol and many pharmaceutical drugs like cefozopran, olaparib, talazoparib, and cadralazine.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Dorina Mantu et al.
European journal of medicinal chemistry, 45(11), 5164-5168 (2010-09-04)
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds
Pyridazinium-based ionic liquids as novel and green corrosion inhibitors of carbon steel in acid medium: electrochemical and molecular dynamics simulation studies
El-Hajjaji F, et al.
Journal of Molecular Liquids, 249(1), 997-1008 (2018)
Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
Popovici L, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 230-243 (2019)
Ying Zhao et al.
ChemMedChem, 7(5), 861-870 (2012-03-15)
Dihydropteroate synthase (DHPS) is the validated drug target for sulfonamide antimicrobial therapy. However, due to widespread drug resistance and poor tolerance, the use of sulfonamide antibiotics is now limited. The pterin binding pocket in DHPS is highly conserved and is
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
He Z-X, et al.
European Journal of Medicinal Chemistry, 112946-112946 (2020)
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