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Merck

840030C

Avanti

06:0 PS

Avanti Research™ - A Croda Brand

Synonym(s):

PS(6:0/6:0)

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About This Item

Empirical Formula (Hill Notation):
C18H33NO10PNa
CAS Number:
321862-85-5
Molecular Weight:
477.42
UNSPSC Code:
51191904
NACRES:
NA.25

Key Documents

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Product Name

06:0 PS, 1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI key

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (840030C-10mg), pkg of 1 × 2.5 mL (840030C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840030C

concentration

10 mg/mL (840030C-10mg), 10 mg/mL (840030C-25mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

General description

Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules like bone, enamel and dentin.

Application

06:0 PS may be used:
  • to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine)
  • to prepare phosphatidylserine (PS) liposomes
  • as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay

Biochem/physiol Actions

Phosphoserine (PS) can be used as a template moiety for the recognition of cancer antigen 125 (CA 125). It is essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans and is blood-brain barrier traversable. PS actively participates in the locomotor functions.

Packaging

5 mL Clear Glass Sealed Ampule (840030C-10mg)
5 mL Clear Glass Sealed Ampule (840030C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

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Athena Sudom et al.
The Journal of biological chemistry, 293(32), 12634-12646 (2018-05-26)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular
Lhaj Benaziz et al.
Journal of colloid and interface science, 238(1), 48-53 (2001-05-15)
The adsorption of phosphoserine and serine was studied to determine the effect of amino acid functional groups on the surface reactivity of synthetic poorly crystalline apatite similar to bone mineral. The experimental results for phosphoserine and serine uptake agree respectively
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
Sibel Büyüktiryaki et al.
Talanta, 167, 172-180 (2017-03-28)
Cancer antigen 125 (CA 125) is widely used as diagnostic biomarker for ovarian cancer. Change in the concentration level of CA 125 is associated with disease progression or regression. CA 125 posseses a phosphorylation site and protein backbone is phosphorylated
P J Hergenrother et al.
Analytical biochemistry, 251(1), 45-49 (1997-08-15)
The kinetic parameters of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus (PLCBc) have been evaluated for phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine substrates with a new assay based on the quantitation of inorganic phosphate (Pi). Treatment of the phosphomonoester product of the
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