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Merck

880129C

Avanti

DSPE-PEG(2000) Biotin

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
385437-57-0
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

DSPE-PEG(2000) Biotin, Avanti Research™ - A Croda Brand 880129C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CCCC[C@](SC[C@@]1(NC(N2)=O)[H])([C@]12[H])[H])=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (880129C-10mg), pkg of 1 × 2 mL (880129C-50mg), pkg of 1 × 2.5 mL (880129C-25mg), pkg of 1 × 4 mL (880129C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880129C

concentration

10 mg/mL (880129C-10mg), 10 mg/mL (880129C-25mg), 25 mg/mL (880129C-100mg), 25 mg/mL (880129C-50mg)

shipped in

dry ice

storage temp.

−20°C

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (DSPE-PEG(2000) based micelles display a spheroids shape and are effective agents for drug delivery. Their size ranges between 18 nm to 90 nm. It is used with functional groups like biotin added as conjugate.

Application

DSPE-PEG(2000) Biotin has been used in the generation of biotinylated lipid-coated microbubbles for adhering to human umbilical vein endothelial cells (HUVECs) and chicken embryo for ultrasound studies. It has also been used for the generation of giant unilamellar lipid vesicles (GUVs) for live cell fusion studies.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (DSPE-PEG(2000)) Biotin is used in capsule surface modification.

Packaging

5 mL Clear Glass Sealed Ampule (880129C-100mg)
5 mL Clear Glass Sealed Ampule (880129C-10mg)
5 mL Clear Glass Sealed Ampule (880129C-25mg)
5 mL Clear Glass Sealed Ampule (880129C-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

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SPIO labeling of endothelial cells using ultrasound and targeted microbubbles at diagnostic pressures
Skachkov I, et al.
Testing, 13(9), e0204354-e0204354 (2018)
Wen-Qun Li et al.
International journal of nanomedicine, 14, 8345-8360 (2019-11-07)
The protective role of puerarin (PUE) against myocardial infarction is closely related to its regulation on mitochondria. However, free PUE can hardly reach the mitochondria of ischemic cardiomyocytes due to the lack of mitochondrial targeting of PUE. Here PUE was
In vivo characterization of ultrasound contrast agents: microbubble spectroscopy in a chicken embryo
Faez T, et al.
Ultrasound in Medicine & Biology, 38(9), 1608-1617 (2012)
Hot-nanoparticle-mediated fusion of selected cells
Bahadori A, et al.
Nano Research, 10(6), 2034-2045 (2017)
Raquel Díaz-López et al.
Biomaterials, 30(8), 1462-1472 (2008-12-23)
We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification.
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