573098
JAK2 Inhibitor III, SD-1029
The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2.
Synonym(s):
JAK2 Inhibitor III, SD-1029, 9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488
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About This Item
Empirical Formula (Hill Notation):
C25H30Cl2N2O3 · 2HBr
CAS Number:
Molecular Weight:
639.25
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥80% (sum of isomers, HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥80% (sum of isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Duan, Z., et al. 2006. Clin. Cancer Res.12, 6844.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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