N,O-Bis(trimethylsilyl)acetamide

Name: <I>N</I>,<I>O</I>-Bis(trimethylsilyl)acetamide
Brand: SIAL

derivatization grade (GC derivatization), LiChropur^™, ≥98.5% (GC)

Synonym(s):

BSA

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About This Item

Linear Formula:

CH₃C[=NSi(CH₃)₃]OSi(CH₃)₃

CAS Number:

10416-59-8

Molecular Weight:

203.43

UNSPSC Code:

41116105

NACRES:

NA.22

PubChem Substance ID:

329750807

EC Number:

233-892-7

Beilstein/REAXYS Number:

1306669

MDL number:

MFCD00008270

Product Name

N,O-Bis(trimethylsilyl)acetamide, derivatization grade (GC derivatization), LiChropur^™, ≥98.5% (GC)

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

grade

derivatization grade (GC derivatization)

assay

≥98.5% (GC)

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.417 (lit.)
n20/D 1.417

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

Quality Level

100

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Related Categories

Analytical Reagents

Chromatography & Spectroscopy Reagents

Application

Learn more in the Product Information

Suitable for the derivatization of 2-amino-2-dexoxyhexoses, ecdysones, hexosamines in glycosaminoglycans, 18-hydroxycorticosteroids, 15-Oxo-prostaglandin F_2α,prostaglandins A,B and E and F, F_2α, prostaglandins and metabolites, prostaglandins Emetabolites, sugar phosphates, steroids and testosterone.

General description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Other Notes

Powerful silylating agent

Reagent for o-trimethylsilyl-aldono-1,4-lactones, trimethylsilyl and trimethylsilyl ether.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS02,GHS05,GHS07

signalword

Danger

hcodes

H226,H302,H314

pcodes

P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

111.2 °F - closed cup

flash_point_c

44 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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K. Blau et al.

Handbook of Derivatives for Chromatography (1993)

J. Heberle et al.

Silylating Agents, 2nd ed. (1995)

Houben-Weyl Methods of Molecular Transformations. Heteroatom Analogues of Aldehydes and Ketones.

Aggarwal VK

Science of Synthesis Knowledge Updates, 27, 593-594 (2014)

Analysis of the prostaglandins E by glass capillary gas chromatography with electron capture detection.

M Korteweg et al.

Prostaglandins, 13(6), 1221-1223 (1977-06-01)

Determination of phenols in water samples by single-drop microextraction followed by in-syringe derivatization and gas chromatography-mass spectrometric detection.

Mohammad Saraji et al.

Journal of chromatography. A, 1098(1-2), 30-36 (2005-11-30)

Trace analysis of phenolic compounds in water was performed by coupling single-drop microextraction (SDME) with in-syringe derivatization of the analytes and GC-MS analysis. The analytes were extracted from a 3ml sample solution using 2.5microl of hexyl acetate. After extraction, derivatization

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