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Merck

A3658

N8-Acetylspermidine dihydrochloride

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C9H21N3O · 2HCl
CAS Number:
34450-15-2
Molecular Weight:
260.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329770841
MDL number:
MFCD00058263
Beilstein/REAXYS Number:
3698131

Key Documents

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Product Name

N8-Acetylspermidine dihydrochloride, analytical standard

InChI

1S/C9H21N3O.2ClH/c1-9(13)12-8-3-2-6-11-7-4-5-10;;/h11H,2-8,10H2,1H3,(H,12,13);2*1H

SMILES string

Cl.Cl.CC(=O)NCCCCNCCCN

InChI key

BWGUIRARVGYOIR-UHFFFAOYSA-N

grade

analytical standard

technique(s)

mass spectrometry (MS): suitable

format

neat

storage temp.

2-8°C

Quality Level

200

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000506332
0000506332
0000484565
0000484565
0000236746

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M Lurdes et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 43(10), 990-994 (1989-11-01)
The synthesis of all three monoacetylated spermidines is reported. N4-Acetylspermidine was obtained in four steps from spermidine via the triacetylated intermediate by selective deacetylation after exhaustive t-butoxycarbonylation as well as directly from a previously described protected precursor. N1-Acetylspermidine and N8-acetylspermidine
M D Berry
Journal of neuroscience research, 55(3), 341-351 (1999-05-29)
The endogenous polyamines have been extensively studied with respect to their role in cellular death mechanisms, although the results are contradictory. In contrast, their primary metabolites, the N-acetyl polyamines, have not been much studied. It has been hypothesized that the
O P Shukla et al.
Molecular and biochemical parasitology, 51(1), 91-98 (1992-03-01)
Polyamine oxidase plays a key role in the catabolism of polyamines and regeneration of spermidine and putrescine. The mammalian enzyme utilises N1-acetylspermidine, and N8-acetylspermidine, although formed in the mammals, is not catabolised further. We have characterised an enzyme from Acanthamoeba
A G Halline et al.
Cancer research, 49(17), 4721-4723 (1989-09-01)
1,2-Dimethylhydrazine (DMH) is a potent procarcinogen with selectivity for the colon. Recently, it has been demonstrated that levels of N1-acetylspermidine were elevated 2-3-fold in colonic tumors induced by this agent compared to control tissues. To determine whether alterations in the
T S Weiss et al.
Cell proliferation, 35(5), 257-267 (2002-09-25)
Extracellular matrices, like collagen layers, play an important role in preventing dedifferentiation of hepatocytes in long-term culture experiments. It has also been shown that polyamines are crucial for cell growth and liver differentiation - regeneration. Primary cultured hepatocytes with their
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