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Merck

S0700000

Sodium calcium edetate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Ethylenediaminetetraacetic acid calcium disodium salt, (Ethylenedinitrilo)tetraacetic acid calcium disodium salt, EDTA calcium disodium salt, Edathamil

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About This Item

Linear Formula:
C10H12N2O8CaNa2
CAS Number:
62-33-9
Molecular Weight:
374.27
NACRES:
NA.24
PubChem Substance ID:
329824436
UNSPSC Code:
41116107
MDL number:
MFCD00148919

Key Documents

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Product Name

Sodium calcium edetate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4

SMILES string

[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI key

SHWNNYZBHZIQQV-UHFFFAOYSA-J

grade

pharmaceutical primary standard

API family

edta

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Related Categories

Application

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors. As this form is already chelated with Ca2+, it is selective for divalent cations with greater affinity for EDTA, which it will exchange for Ca2+.
Used to eliminate inhibition of enzyme catalyzed reactions due to traces of heavy metals

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Sally Bradberry et al.
Clinical toxicology (Philadelphia, Pa.), 47(9), 841-858 (2009-10-27)
This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, blood and tissue lead concentrations, resolution of features and survival) of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the
Gervasio A Lamas et al.
American heart journal, 168(1), 37-44 (2014-06-24)
Disodium ethylenediaminetetraacetic acid (EDTA) reduced adverse cardiac outcomes in a factorial trial also testing oral vitamins. This report describes the intent-to-treat comparison of the 4 factorial groups overall and in patients with diabetes. This was a double-blind, placebo-controlled, 2 ×
David Voglar et al.
Environmental technology, 35(9-12), 1389-1400 (2014-04-08)
We demonstrate here, in a pilot-scale experiment, the feasibility of ethylenediaminetetraacetate (EDTA)based washing technology for soils contaminated with potentially toxic metals. Acid precipitation coupled to initial alkaline toxic metal removal and an electrochemical advanced oxidation process were used for average
Pseudothrombocytopenia in a patient receiving romiplostim for immune thrombocytopenic purpura.
Claudio Fozza et al.
Annals of hematology, 93(5), 899-900 (2013-10-02)
Il Joong Park et al.
Archives of pathology & laboratory medicine, 138(8), 1077-1082 (2014-07-31)
The Samsung LABGEO(HC10) Hematology Analyzer (LABGEO(HC10)) is a recently developed automated hematology analyzer that uses impedance technologies. The analyzer provides 18 parameters including 3-part differential at a maximum rate of 80 samples per hour. To evaluate the performance of the
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