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T4885

Trichloroacetic acid

≥99.0% (titration), powder or crystals

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
76-03-9
Molecular Weight:
163.39
NACRES:
NA.21
PubChem Substance ID:
24900233
UNSPSC Code:
12352100
EC Number:
200-927-2
MDL number:
MFCD00004177
Beilstein/REAXYS Number:
970119
Assay:
≥99.0% (titration)
Form:
powder or crystals
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Product Name

Trichloroacetic acid, ≥99.0% (titration)

vapor density

<1 (vs air)

Quality Level

200

vapor pressure

1 mmHg ( 51 °C)

assay

≥99.0% (titration)

form

powder or crystals

refractive index

n20/D 1.62 (lit.)

pH

1 (at 25 °C, 81,7  g/L)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 1 g/10 mL

density

1.62 g/mL at 25 °C (lit.)

functional group

carboxylic acid, chloro

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.
Trichloroacetic acid (TCA) can be used as a catalyst to synthesize:
  • β-enaminones via condensation reaction of 1,3-dicarbonyl compounds and amines.
  • 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives via four-component condensation reaction of ethyl acetoacetate, phenylhydrazine, malononitrile, and aromatic aldehydes.
  • Tetrahydrobenzo[a]xanthen-11-ones by three-component reaction of aldehydes, 2-naphthol and dimedone.

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pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H314,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

wgk

WGK 2

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Storage Class

8A - Combustible corrosive hazardous materials

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Certificates of Analysis (COA)

Lot/Batch Number
0000487361
0000487361
0000462117
0000451846
0000450296

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Efficient Synthesis of β-Enaminones and β-Enamino Esters Using Tris (Hydrogensulfato) Boron or Trichloroacetic Acid as Catalysts
Karimi-Jaberi Z and Takmilifard Z
European Chemical Bulletin, 2, 211-213 (2013)
Expeditious, four-component synthesis of 1, 4-dihydropyrano [2, 3-c] pyrazole derivatives catalyzed by trichloroacetic acid or ceric sulfate
Jaberi ZK, et al.
Acta Chimica Slovenica, 60(1), 105-108 (2013)
Efficient, one-pot synthesis of tetrahydrobenzo [a] xanthen-11-ones and dibenzo [a, j] xanthenes using trichloroacetic acid as a solid heterogeneous catalyst under solvent-free conditions
Jaber ZK, et al.
E-Journal of Chemistry, 8(4), 1895-1899 (2011)
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