375810
Periodic acid
ACS reagent, 99%
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About This Item
Empirical Formula (Hill Notation):
H5IO6
CAS Number:
Molecular Weight:
227.94
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
233-937-0
MDL number:
Assay:
99%, 99.0-101.0% (ACS specification)
Form:
powder or crystals
Grade:
ACS reagent
grade
ACS reagent
Quality Level
assay
99%, 99.0-101.0% (ACS specification)
form
powder or crystals
reaction suitability
reaction type: C-H Activation, reagent type: catalyst, reagent type: oxidant
impurities
≤0.01% insolubles, ≤0.01% other halogens
ign. residue
≤0.01%
mp
122 °C (lit.)
solubility
water: soluble
anion traces
sulfate (SO42-): ≤0.01%
cation traces
Fe: ≤0.003%, heavy metals: ≤0.005%
application(s)
histology
SMILES string
OI(O)(O)(O)(O)=O
InChI
1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
InChI key
TWLXDPFBEPBAQB-UHFFFAOYSA-N
General description
Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid. Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiff′s reagent. Therefore periodic-acid-Schiff′s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.
Application
Periodic acid may be used in the following reactions:
- Oxidation of alcohols to ketones and aldehydes.
- Oxidation hydroxylamine derivatives.
- Oxidation of arenes to quinones.
- Deprotection of the dithio- and oxathio-derivatives.
- Oxidative degradation of epoxidized natural rubber (ENR).
- Oxidation of urazoles and bis-urazoles to triazolinediones.
- Oxidative cleavage of glucosazone.
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signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
target_organs
Thyroid
Storage Class
5.1A - Strongly oxidizing hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Deblocking of dithioacetals and oxathioacetals using periodic acid under mild nonaqueous conditions.
Shi XX, et al.
Tetrahedron Letters, 37(25), 4331-4334 (1996)
The sialic acids. XI. A periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides.
G W Jourdian et al.
The Journal of biological chemistry, 246(2), 430-435 (1971-01-25)
The Action of Periodic Acid on Glucose Phenylosazone.
Chargaff E and Magasanik B.
Journal of the American Chemical Society, 69(6), 1459-1461 (1947)