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Merck

B1502

Brain Extract from bovine brain

Type I, Folch Fraction I

Synonym(s):

Brain Extract from Bovine

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352211
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biological source

bovine brain

type

Type I

form

powder

lipid type

phosphoglycerides

storage temp.

−20°C

Quality Level

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General description

Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.

Application

Brain Extract from bovine brain has been used:
  • to prepare small unilamellar vesicles
  • in lipid binding assay
  • to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
  • in liposome and protein self-aggregation assays

Biochem/physiol Actions

Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.

Packaging

Sealed ampule.

Other Notes

Contains phosphatidylinositol phosphatidylserine,other brain lipids.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Cholesterol and Fat Metabolism in Alzheimer?s Disease
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders, 161-193 (2017)
Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Low C, et al.
Biophysical Journal, 95(9), 4315-4323 (2008)
Fei Ye et al.
eLife, 7 (2018-12-12)
INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cβ, PLCβ), a key step for
Jonathan P Giblin et al.
Molecular neurobiology, 56(4), 2524-2541 (2018-07-25)
The background K+ channel TRESK regulates sensory neuron excitability, and changes in its function/expression contribute to neuronal hyperexcitability after injury/inflammation, making it an attractive therapeutic target for pain-related disorders. Factors that change lipid bilayer composition/properties (including volatile anesthetics, chloroform, chlorpromazine
Measurement of phosphoinositides in the zebrafish Danio rerio
Jones DR, et al.
Nature Protocols, 8(6), 1058-1058 (2013)

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