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Merck

B1651

Bradykinin Fragment 1-7

≥97% (HPLC)

Synonym(s):

1-7-Bradykinin

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About This Item

Empirical Formula (Hill Notation):
C35H52N10O9
CAS Number:
23815-87-4
Molecular Weight:
756.85
UNSPSC Code:
12352209
PubChem Substance ID:
24891606
NACRES:
NA.26
MDL number:
MFCD00076262

Key Documents

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Product Name

Bradykinin Fragment 1-7, ≥97% (HPLC)

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O

InChI

1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)

InChI key

CRROPKNGCGVIOG-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01161

storage temp.

−20°C

Quality Level

200

Gene Information

rat ... Nppa(24602)

Related Categories

Application

Bradykinin Fragment 1-7 has been used as an external calibrant/standard in the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of protein spots.
Bradykinin Fragment 1-7 is used in research on the specificity and kinetics of kininase(s).

Biochem/physiol Actions

Bradykinin (BK) is a pro-inflammatory mediator and a neuromediator. It modulates several vascular and renal functions. Bradykinin (BK) plays a key role in inducing vascular permeability and mitogenesis. It helps to activate the liberation of nitric oxide in inflammatory and cancer tissues.

General description

Bradykinin fragment 1-7 (BK-(1-7)), an endogenous peptide, is present in plasma.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000484331
0000484331
0000470621
0000470621
0000408420

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Laura M Jones et al.
Journal of proteome research, 9(6), 2871-2881 (2010-04-16)
The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage
M Bramucci et al.
Acta physiologica Scandinavica, 175(2), 123-128 (2002-05-25)
Angiotensin converting enzyme (ACE) was demonstrated to modulate the production of 17beta-estradiol, progesterone and prostaglandin E2 (PGE2) in frog ovary of Rana esculenta. However, the activity was not mediated by angiotensin II (Ang II). In an attempt to identify the
J M Ribeiro et al.
Experimental parasitology, 89(2), 213-221 (1998-06-27)
Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment
Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors
Souza SI, et al.
15th international conference on miniaturized systems for chemistry and life sciences, Seattle, Washington (2021)
Measurement of des-Phe8-Arg9-bradykinin by enzyme-immunoassay--a useful parameter of plasma kinin release.
M Majima et al.
Advances in experimental medicine and biology, 247B, 331-335 (1989-01-01)
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