P4620
PD 146176
≥98% (HPLC), solid
Synonym(s):
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
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About This Item
Empirical Formula (Hill Notation):
C15H11NS
CAS Number:
Molecular Weight:
237.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
InChI key
ZGOOPZVQMLHPFM-UHFFFAOYSA-N
SMILES string
C1Sc2ccccc2-c3[nH]c4ccccc4c13
InChI
1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
assay
≥98% (HPLC)
form
solid
color
white to beige
solubility
DMSO: soluble >10 mg/mL, H2O: insoluble
Quality Level
Gene Information
human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)
Related Categories
Application
PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.
Biochem/physiol Actions
15-Lipoxygenase inhibitor
PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Retinal pigment epithelium and photoreceptor preconditioning protection requires docosanoid signaling
Knott EJ, et al.
Cellular and Molecular Neurobiology, 38(4), 901-917 (2018)
Chi-Yuan Lee et al.
Micromachines, 11(12) (2020-12-10)
The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or
David M Tobin et al.
PloS one, 8(7), e67828-e67828 (2013-07-23)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here
Jiang Yang et al.
Scientific reports, 9(1), 13316-13316 (2019-09-19)
Ovarian cancer (OvCa), while accounting for only 3% of all women's cancer, is the fifth leading cause of cancer death among women. One of the most significant obstacles to successful OvCa treatment is chemoresistance. The current lack of understanding of
ALOX5AP overexpression in adipose tissue leads to LXA4 production and protection against diet-induced obesity and insulin resistance
Elias I, et al.
Diabetes, 65(8), 2139-2150 (2016)
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