SAB4500003
Anti-BCL-2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Species reactivity:
rat, mouse, human
Citations:
34
Technique(s):
ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 26 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BCL2(596)
Application
Anti-BCL-2 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
BCL2 is an apoptosis regulator that is expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. BCL2 may also regulate autophagy during starvation . Anti-BCL-2 antibodies are specific for endogenous levels of total BCL-2 protein in rats, humans and mice.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
B-cell lymphoma 2 (BCL-2) is an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. It is a target gene of nuclear factor kappa B (NF-kB). The gene encoding BCL-2 is localized on human chromosome 18q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human BCL-2.
Immunogen Range: 46-95
Immunogen Range: 46-95
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP
The Journal of Biological Chemistry (2006)
Analysis of necroptotic proteins in failing human hearts
Szobi A, et al.
Journal of Translational Medicine (2017)
Bcl-2 is a critical mediator of intestinal transformation.
Heijden M, et al.
Nature Communications (2016)
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation
Lichy M, et al.
Journal of Cellular and Molecular Medicine (2019)
Huihui Gao et al.
Veterinary microbiology, 224, 34-42 (2018-10-03)
This study focuses on the effect of outer membrane vesicles (OMVs) in gram-negative bacteria on boar sperm function during in vitro storage. In the 40 ejaculates collected from Guangzhong Black boar, six gram-negative bacterial species were detected by 16S rDNA
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