SML3288
WX8
≥98% (HPLC)
Synonym(s):
1H-Indole-3-carbaldehyde [4-anilino-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone, 1H-Indole-3-carboxaldehyde, [4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone, Ro 91-4714, Ro-91-4714
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About This Item
Empirical Formula (Hill Notation):
C22H22N8O
CAS Number:
Molecular Weight:
414.46
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
C1(NC2=CC=CC=C2)=NC(N/N=C/C3=CNC4=C3C=CC=C4)=NC(N5CCOCC5)=N1
InChI key
NJIKLALXAPYTCW-BUVRLJJBSA-N
Biochem/physiol Actions
Selective phosphoinositide kinase PIKfyve inhibitor with higher antiproliferation potency in A375 cultures than YM201636, chloroquine or hydroxychloroquine.
WX8 (Ro 91-4714) is a selective phosphoinositide kinase PIKfyve inhibitor that disrupts lysosome fission via tubulation, lysosomal trafficking, and heterotypic lysosomes-autophagosomes fusion (0.1-1 µM; U2OS), but not homotypic lysosome fusion. WX8 exhibits cancer-selective antiproliferation activity (IC50 = 48 nM/A375, 200 nM/U2OS; IC50 >10 µM/non-cancer 293T & HFF) with a higher potency than the PIKfyve inhibitor YM201636, or the lysosomal inhibitors chloroquine & hydroxychloroquine (A375 IC50 = 119 nM, 1.7 µM, 1.9 µM, repectively).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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