T2265

Tetraethylammonium chloride

Name: Tetraethylammonium chloride
Brand: SIGMA

synthetic (organic), ≥98% (titration), K+ channels blocker, powder

Synonym(s):

TEA chloride

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About This Item

Linear Formula:

(C₂H₅)₄N(Cl)

CAS Number:

56-34-8

Molecular Weight:

165.70

NACRES:

NA.32

PubChem Substance ID:

24277874

UNSPSC Code:

12352107

EC Number:

200-267-5

MDL number:

MFCD00011828

Beilstein/REAXYS Number:

3563247

Product Name

Tetraethylammonium chloride, ≥98% (titration)

InChI key

YMBCJWGVCUEGHA-UHFFFAOYSA-M

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1

SMILES string

[Cl-].CC[N+](CC)(CC)CC

biological source

synthetic (organic)

assay

≥98% (titration)

form

powder

technique(s)

blocking: suitable

color

white to light yellow

Quality Level

200

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

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Bioactive Small Molecules

Application

Tetraethylammonium chloride (TEAC) has been used:

used for inhibition of peroxynitrite induced relaxation in rat aorta rings
as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons
for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Biochem/physiol Actions

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

Disclaimer

moisture sensitive, handle under argon

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

201.2 °F - closed cup

flash_point_c

94 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction

Sordi R, et al.

British Journal of Pharmacology, 163(6), 1289-1301 (2011)

Dissociation enzyme effects on the potassium currents of inner hair cells isolated from guinea-pig cochlea

Kimitsuki T, et al.

Hearing Research, 199(1-2), 135-139 (2005)

Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro

Li Z, et al.

Naunyn-Schmiedeberg'S Archives of Pharmacology, 384(2), 147-155 (2011)

Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action

Li J, et al.

Toxicology and Applied Pharmacology, 209(3), 269-276 (2005)

Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species

Yang KB, et al.

Chemotherapy, 55(5), 372-380 (2009)

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