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Merck

T5516

3,3′,5-Triiodo-L-thyronine sodium salt

γ-irradiated, powder, suitable for, suitable for cell culture

Synonym(s):

Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3

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About This Item

Empirical Formula (Hill Notation):
C15H11I3NNaO4
CAS Number:
55-06-1
Molecular Weight:
672.96
UNSPSC Code:
12352207
NACRES:
NA.77
PubChem Substance ID:
24900290
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
MFCD00002594
biological source:
synthetic (organic)
form:
powder
assay:
≥90% (HPLC)

Product Name

3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

biological source

synthetic (organic)

sterility

γ-irradiated

assay

≥90% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

suitability

suitable for

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

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Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used:
  • as a supplement in colon organ culture media
  • to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
  • to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride
To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000285428
0000317083
0000284104
SLCQ7632
0000317083

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Hormonal regulation of mannan-binding lectin synthesis in hepatocytes
Sorensen CM, et al.
Clinical and Experimental Immunology, 145(1), 173-182 (2006)
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Irene Antolino-Lobo et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1105-1112 (2010-04-15)
Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
C M Sørensen et al.
Clinical and experimental immunology, 145(1), 173-182 (2006-06-24)
Activation of the complement system via the plasma protein mannan-binding lectin (MBL) provides a first line of defence against infections. The plasma level of MBL is, in part, determined genetically, but may also be influenced by different hormones in vivo.
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