T8826
Terbinafine hydrochloride
Synonym(s):
trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H25N · HCl
CAS Number:
Molecular Weight:
327.89
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51302503
MDL number:
assay
≥98%
Quality Level
form
powder
color
white to faint beige
solubility
methanol: soluble 50 mg/mL
antibiotic activity spectrum
fungi, yeast
mode of action
enzyme | inhibits
SMILES string
Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
InChI
1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
InChI key
BWMISRWJRUSYEX-SZKNIZGXSA-N
General description
Allylamine derivative.
Application
Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.
Biochem/physiol Actions
Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.
Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Disclaimer
The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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J Oremusová et al.
Die Pharmazie, 62(4), 273-277 (2007-05-09)
In this study the adsorption, partition and releasing balances of terbinafine hydrochloride have been studied. The adsorption isotherms of antifugal drug terbinafine hydrochloride (terbinafine), on the base of its adsorption from aqueous solutions on the surface of activated charcoal, were
Abdul-Rehman Phull et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 16(4), 495-506 (2019-11-13)
Silver nanoparticles synthesized by the bio-green method have been applied to various biomedical applications. These procedures are simple, eco-friendly and serve as an alternative to complex chemical methods for the preparation of nanomaterials. In the present study, phytosynthesis of silver
Akira Kotani et al.
Journal of chromatography. A, 1621, 461077-461077 (2020-04-28)
A previous paper of this series of study put forward a basic model of an automated system for predicting detection limits and showed its application to a simple example of isocratic high-performance liquid chromatography (HPLC). This paper describes an expansion