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Merck

W4262

1400W dihydrochloride

>98%, potent and selective iNOS inhibitor , solid

Synonym(s):

N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15N3 · 2 HCl
CAS Number:
214358-33-5
Molecular Weight:
250.17
UNSPSC Code:
12352200
PubChem Substance ID:
24278778
NACRES:
NA.77
MDL number:
MFCD03428622

Product Name

1400W dihydrochloride, >98%, solid

SMILES string

Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1

InChI key

WDJHSQZCZGPGAA-UHFFFAOYSA-N

InChI

1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H

assay

>98%

form

solid

storage condition

desiccated

originator

GlaxoSmithKline

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Gene Information

human ... NOS1(4842), NOS2(4843), NOS3(4846)

Related Categories

Application

1400W dihydrochloride has been used:
  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
  • to study its efficacy on renal ischemia/ reperfusion injury in rats
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

Biochem/physiol Actions

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000132679
0000132679
0000131222
0000107881
0000060237

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Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
View All Related Papers

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Product Information Sheet - W4262

Product Information Sheet

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