901594
Diisopropylcarbodiimide solution
1 M in THF
Synonym(s):
Diisopropylmethanediimine
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About This Item
form
liquid
reaction suitability
reaction type: Coupling Reactions
concentration
1 M in THF
density
0.870 g/mL
application(s)
peptide synthesis
SMILES string
N(=C=NC(C)C)C(C)C
InChI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChI key
BDNKZNFMNDZQMI-UHFFFAOYSA-N
Application
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in tetrahydrofuran for more convenient handling.
Coupling reagent for peptide syntheses.
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signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
2.0 °F
flash_point_c
-16.66 °C
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Stéphane Chantepie et al.
PloS one, 10(7), e0133140-e0133140 (2015-07-29)
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Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Tetrahedron Letters, 35, 5981-5981 (1994)