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Merck

D2954000

Dobutamine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H23NO3 · HCl
CAS Number:
49745-95-1
Molecular Weight:
337.84
NACRES:
NA.24
PubChem Substance ID:
329798764
UNSPSC Code:
41116107
MDL number:
MFCD00153795

Product Name

Dobutamine hydrochloride, European Pharmacopoeia (EP) Reference Standard

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

grade

pharmaceutical primary standard

API family

dobutamine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRB1(153), ADRB2(154)

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Application

Dobutamine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Shin Lin et al.
Journal of the American Heart Association, 2(2), e000097-e000097 (2013-04-18)
Patients with a myocardial bridge (MB) and no significant obstructive coronary artery disease (CAD) may experience angina presumably from ischemia, but noninvasive assessment has been limited and the underlying mechanism poorly understood. This study seeks to correlate a novel exercise
Sahadev T Reddy et al.
Transplantation, 96(9), 827-833 (2013-08-29)
Preoperative cardiovascular risk stratification in orthotopic liver transplantation candidates has proven challenging due to limitations of current noninvasive modalities. Additionally, the preoperative workup is logistically cumbersome and expensive given the need for separate cardiac, vascular, and abdominal imaging. We evaluated
Jamshid Shirani et al.
The American journal of cardiology, 112(9), 1293-1297 (2013-07-23)
In patients with obstructive coronary artery disease, electrocardiographic (ECG) ST-segment elevation (STE) is frequently seen during dobutamine stress echocardiography (DSE) in leads overlying previous transmural left ventricular (LV) myocardial infarction. The mechanism of occasional STE during DSE in LV region
Daniel Augustine et al.
Circulation research, 114(1), 109-113 (2013-10-22)
Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. We measured a
Philipp Emanuel Bartko et al.
Circulation. Cardiovascular imaging, 6(2), 268-276 (2013-01-01)
Decision making in patients with low flow-low gradient aortic stenosis mainly depends on the actual stenosis severity and left ventricular function, which is of prognostic importance. We used 2-dimensional strain parameters measured by speckle tracking at rest and during dobutamine
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