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Merck

V0500

L-Valine

≥98% (HPLC), suitable for thin layer chromatography (TLC)

Synonym(s):

(S)-α-Aminoisovaleric acid, L-2-Amino-3-methylbutanoic acid

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About This Item

Linear Formula:
(CH3)2CHCH(NH2)CO2H
CAS Number:
72-18-4
Molecular Weight:
117.15
NACRES:
NA.26
PubChem Substance ID:
24900695
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-773-6
MDL number:
MFCD00064220
Beilstein/REAXYS Number:
1721136

Product Name

L-Valine, reagent grade, ≥98% (HPLC)

InChI key

KZSNJWFQEVHDMF-BYPYZUCNSA-N

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

SMILES string

CC(C)[C@H](N)C(O)=O

grade

reagent grade

assay

≥98% (HPLC)

form

powder

technique(s)

thin layer chromatography (TLC): suitable

color

white

mp

295-300 °C (subl.) (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

Quality Level

200

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Application

  • L-Valine has been used as a standard in thin layer chromatography.
  • It has been used as a supplement in Grace′s antheraea medium for the culture of cells and tissue from invertebrates.
  • It has been used in the preparation of starvation media to study the role of relA gene in antibiotic resistance in E. coli.

Biochem/physiol Actions

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA) maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Long term deficiency of L-Valine leads to growth failure, organ damage and loss of muscle mass.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000468768
0000468768
0000498357
0000498355
0000498355

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On the limited role of relA in kanamycin and amino acid starvation induced stringency and subsequent antibiotic cross-protection in Escherichia coli
Chiang
Journal of Experimental Microbiology and Immunology, 15, 59-63 (2011)
Martin Kohlmeier
Nutrient Metabolism: Structures, Functions, and Genes, 390-390 (2015)
Preparation of several media for the culture of tissues and cells from invertebrates.
Vaughn
TCA Manual, 527-537 (1977)
Zhesi Zhu et al.
Nucleic acids research, 49(1), 177-189 (2020-12-15)
Short-chain acylations of lysine residues in eukaryotic proteins are recognized as essential posttranslational chemical modifications (PTMs) that regulate cellular processes from transcription, cell cycle, metabolism, to signal transduction. Lysine butyrylation was initially discovered as a normal straight chain butyrylation (Knbu).
Zhe Yang et al.
Cell research, 28(10), 1013-1025 (2018-09-14)
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that
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