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Merck

D9760

L-(−)-Dithiothreitol

≥95% (titration)

Synonym(s):

(−)-Cleland’s Reagent, (2R,3R)-1,4-Dimercapto-2,3-butanediol, L-DTT, Cleland reagent chiral

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About This Item

Empirical Formula (Hill Notation):
C4H10O2S2
CAS Number:
16096-97-2
Molecular Weight:
154.25
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24894326
EC Number:
240-263-0
Beilstein/REAXYS Number:
2036371
MDL number:
MFCD00064305

Product Name

L-(−)-Dithiothreitol, ≥95% (titration)

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChI key

VHJLVAABSRFDPM-IMJSIDKUSA-N

SMILES string

O[C@@H](CS)[C@@H](O)CS

assay

≥95% (titration)

form

powder

color

white

mp

49 - 51 °C ((120 - 124 °F))

solubility

H2O: 50 mg/mL, clear to hazy, colorless

storage temp.

−20°C

Quality Level

100

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Application

L-DTT [(2R,3R)-1,4-dimercapto-2,3-butanediol; L-dithiothreitol], a chiral bidentate dithiol with two stereogenic centers, may be used in chiroptical response research. L-DDT is proposed as a stereoselective reducing agent for disulfide bridges in complex molecules.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS7914
MKCT2496
WXBD9744V
MKCQ3488
MKCP4074

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Hermann Bultmann et al.
Antimicrobial agents and chemotherapy, 51(5), 1596-1607 (2007-01-31)
Previous studies have shown that peptides containing the protein transduction domain (PTD) of the human immunodeficiency virus tat protein (GRKKRRQRRR) were effective inhibitors of herpes simplex virus type 1 (HSV-1) entry (H. Bultmann and C. R. Brandt, J. Biol. Chem.
Julia Schueler et al.
Cells, 8(7) (2019-07-22)
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kinase inhibitors, the
Valérie Robin et al.
Molecular therapy. Nucleic acids, 7, 81-89 (2017-06-19)
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease is
Hiroshi Yao et al.
Langmuir : the ACS journal of surfaces and colloids, 29(21), 6444-6451 (2013-05-03)
We here present a study of cross-linking chemistry of optically inactive monothiol-protected gold clusters by chiral bidentate dithiol with two stereogenic centers, (2R,3R)-1,4-dimercapto-2,3-butanediol (L-dithiothreitol; L-DTT), and explore the impacts of the cross-linking on their chiroptical responses. The pristine protective ligand
Stefan Knoppe et al.
Chimia, 67(4), 236-239 (2013-08-24)
Chiral thiolate-protected gold clusters of atomic precision have gained increasing interest in recent years due to their potential use in catalysis, sensing or bioapplications. While the protection of gold clusters with chiral ligands is a rather trivial task, it was
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