G1001

D-Glutamic acid

Name: <SC>D</SC>-Glutamic acid
Brand: SIGMA

≥99% (TLC), suitable for ligand binding assays

Synonym(s):

(R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid, D-Glu, R-(−)-1-Aminopropane-1,3-dicarboxylic acid

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About This Item

Linear Formula:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS Number:

6893-26-1

Molecular Weight:

147.13

NACRES:

NA.32

PubChem Substance ID:

24895031

UNSPSC Code:

12352209

EC Number:

230-000-8

MDL number:

MFCD00063112

Beilstein/REAXYS Number:

1723800

Product Name

D-Glutamic acid, ≥99% (TLC)

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1

InChI key

WHUUTDBJXJRKMK-GSVOUGTGSA-N

SMILES string

N[C@H](CCC(O)=O)C(O)=O

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

200-202 °C (subl.) (lit.)

Quality Level

200

Gene Information

human ... CCR2(1231)

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Application

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

General description

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Allosteric control of an ionotropic glutamate receptor with an optical switch.

Matthew Volgraf et al.

Nature chemical biology, 2(1), 47-52 (2006-01-13)

The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We

Hybrid Steered Molecular Dynamics-Docking: An Efficient Solution to the Problem of Ranking Inhibitor Affinities Against a Flexible Drug Target.

Katie L Whalen et al.

Molecular informatics, 30(5), 459-471 (2011-07-09)

Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a

Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan.

P Doublet et al.

Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)

The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by

A descending dopamine pathway conserved from basal vertebrates to mammals.

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Proceedings of the National Academy of Sciences of the United States of America, 113(17), E2440-E2449 (2016-04-14)

Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive

Subthalamic GAD gene therapy in a Parkinson's disease rat model.

Jia Luo et al.

Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)

The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we

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