J4455
JSH-23
≥98% (HPLC), NF-kB nuclear translocation inhibitor, solid
Synonym(s):
4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
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About This Item
Empirical Formula (Hill Notation):
C16H20N2
CAS Number:
Molecular Weight:
240.34
UNSPSC Code:
51111800
NACRES:
NA.77
Product Name
JSH-23, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
off-white to gray-pink
solubility
DMSO: >10 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
Application
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Biochem/physiol Actions
JSH-23 is an inhibitor of NF-kB nuclear translocation.
JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
Other Notes
Light and air sensitive.
Storage Class
11 - Combustible Solids
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
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L Shi et al.
Oncogene, 36(12), 1631-1643 (2016-11-22)
The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
Journal of Neuroinflammation, 12, 137-137 (2015)