Skip to Content
Merck

N7537

NSC 663284

≥98% (HPLC), solid

Synonym(s):

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C15H16ClN3O3
CAS Number:
383907-43-5
Molecular Weight:
321.76
NACRES:
NA.77
PubChem Substance ID:
24724556
UNSPSC Code:
12352200
MDL number:
MFCD08276924

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

NSC 663284, ≥98% (HPLC), solid

InChI key

BMKPVDQDJQWBPD-UHFFFAOYSA-N

SMILES string

ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O

InChI

1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

red

solubility

DMSO: ≥10 mg/mL
H2O: insoluble

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CDC25B(994), DUSP3(1845), PTPN1(5770)

Related Categories

Biochem/physiol Actions

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

470.1 °F

flash_point_c

243.4 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000522316
0000522316
0000486090
0000486090
0000142371

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kizuna is a novel mitotic substrate for CDC25B phosphatase
Thomas Y, et al.
Cell Cycle, 13(24), 3867-3877 (2014)
Inhibition of DUSP13B Activity by NSC 663284
Lee I S, et al.
Bulletin of the Korean Chemical Society,, 33(10), 3505-3507 (2012)
Utility of resazurin, horseradish peroxidase, and NMR assays to identify redox-related false-positive behavior in high-throughput screens
Tarnowski M, et al.
Assay and Drug Development Technologies, 16(3), 171-191 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service