N8161
NS309
≥98% (HPLC), Ca2+-activated IK/SK potassium channel activator, solid
Synonym(s):
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
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About This Item
Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
Molecular Weight:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
NS309, ≥98% (HPLC), solid
SMILES string
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12
InChI key
CVOUSAVHMDXCKG-UHFFFAOYSA-N
InChI
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: 22 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
NS309 is a Ca2+-activated IK/SK potassium channel activator.
Disclaimer
air sensitive
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Cara C Rada et al.
American journal of physiology. Endocrinology and metabolism, 307(10), E935-E943 (2014-09-25)
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of uteroplacental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction (IUGR). Potassium channels have been recognized as
Kanwal Sakhi et al.
The Journal of physiology, 592(4), 587-603 (2013-11-20)
Intrinsic daily or circadian rhythms arise through the outputs of the master circadian clock in the brain's suprachiasmatic nuclei (SCN) as well as circadian oscillators in other brain sites and peripheral tissues. SCN neurones contain an intracellular molecular clock that
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
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